Yearly Record: 31-39

James Conner Under 49.5 Rushing Yards -110

San Francisco has one of the best run defenses in the NFL. They’ve held high level backs like Austin Ekeler, Melvin Gordon, and Clyde Edwards-Helaire under 49.5 rushing yards. They are allowing 82.7 rushing yards per game and 3.4 yards a carry. I am instilling a lot of faith in Kevin Givens and Nick Bosa tonight.

Christian McCaffrey Over 4.5 Receptions -135

Since joining the 49ers early in the season, McCaffrey has played a big role in the pass game. He has three games with over 4.5 receptions and five games over 4.5 targets. Something to keep in mind is that when the Cardinals played Carolina early in the season, the leading pass catcher for the Panthers was Christian McCaffrey with nine grabs.

Robbie Gould Over 2.5 PATs Made -105

This season, Gould has four games where he’s attempted over 2.5 extra points and is 20-21 on extra point attempts. I have a feeling that San Francisco has a good night offensively, and that’ll lead to Gould lining up for extra points. In the past four games, Arizona has allowed an average 29 points. Their defense won’t be able to stop the Deebo Samuel-Christian McCaffrey duo, and that means Gould will cover his over.

Jimmy Garoppolo Over 0.5 Interceptions +115

While Jimmy G only has four picks on the season and has been relatively clean with the ball, the Cardinals defense has a knack for picking off passes. They have seven interceptions on the season, and it comes from all over the field. Three picks have come from linebackers, while four are from defensive backs. Garoppolo hasn’t thrown an interception in two games. It feels due.